Professor, Cell Biology, Department of Biological Sciences
- Cell Biology
- Cell Biology of Cancer
- Developmental Biology
- Biology Seminar
- Current Topics in Biology
- The focus of research in my laboratory is the cell biology of the budding yeast Saccharomyces cerevisiae (also known as brewer’s or baker’s yeast).
- Postdoctoral training, Princeton University, Molecular Biology
- PhD, University of Pennsylvania, Cell and Molecular Biology
- MS, Villanova University, Biology
- BS, Loyola University Maryland (formerly Loyola College), Biology
Many cellular processes occur in both yeast and human cells and are controlled by similar genes. One advantage of budding yeast as a model system is the speed and ease of creating genetic mutants to study different cellular events. We can study the genes regulating cellular processes in yeast, and then apply our knowledge of gene functions and genetic interactions to studies of human disease. We are specifically interested in the regulation of organelle inheritance, as well as in the genetic control of the metaphase to anaphase transition from yeast to humans. Selected Publications: Melloy, P.G. 2019. The anaphase-promoting complex: a key mitotic regulator associated with somatic mutations occurring in cancer. Under Review. Melloy, P.G., and M.D. Rose. 2017. Influence of the bud neck on nuclear envelope fission in Saccharomyces cerevisiae. Experimental Cell Research 358: 390-396. Melloy, P.G. 2014. Using an international p53 mutation database as a foundation for an online laboratory in an upper-level undergraduate biology class. Biochem and Mol Biol Ed 43 (1): 28-32. Melloy, P., Shen, S., White, E. and M. D. Rose. 2009. Distinct roles for key karyogamy proteins during yeast nuclear fusion. Molecular Biology of the Cell 20: 3773-3782. Melloy, P., Shen, S., White, E., McIntosh, J.R., and M.D. Rose. 2007. Nuclear fusion during yeast mating occurs by a three-step pathway. Journal of Cell Biology 179: 659-670.
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